陈晓岚教授

陈晓岚,女,博士,郑州大学特聘教授(学科骨干),二级教授,博士/硕士研究生导师,英国 Reading 大学留学、美国南加州大学高级访问学者;河南省高层次人才,河南省高等学校教学名师;河南省教育厅学术技术带头人,河南省化学会常务理事,郑州大学化学学院教授委员会委员。

主要从事有机磷化学、药物化学、化学生物学等方面研究。在科研和教学方面分别取得了突出的成绩:主持国家科技重大专项子课题、主持完成国家自然科学基金项目多项,获得河南省杰出青年基金、河南省科技创新人才计划、郑州市科技领军人才等人才项目资助;主持两项国家级教学项目:国家双语教学示范课程(2010 质量工程:有机化学)和来华留学英语授课品牌课程(2013 有机化学)。教学累计工作量超过 7000,培养硕士研究生 70 余人、博士研究生 7 人、博士后 8 人;以第一作者或通讯作者在“J. Am. Chem. Soc.”, “Chem. Sci.”, “ACS Catal.”, “Anal. Chem.”, “Green Chem.”, “Chem. Commun.”, “Org. Lett.”, “ChemSusChem”, “Org. Chem. Front.” “ACS Sustainable Chem. Eng.”, “Adv. Synth. Catal.”, “J. Org. Chem.”等国内外著名期刊发表科研论文 130 余篇,其中 SCI 收录论文 110 余篇,总被他引次数达千余次,其中 JCR 一区论文 80 余篇,ESI 前百分之一高被引论文 8 篇,ESI 前千分之一热点论文 2 篇。主持河南省一流本科课程项目1项,主编本科生全英教材2部(“十三五”国家重点图书出版规划项目)。

邮箱:[email protected]

研究方向:有机合成方法学、有机磷化学、药物化学及化学生物学

学术头衔/兼职:

全国磷化学化工学术讨论会暨中国空间科学学会空间暨生命起源与进化专业委员会委员;全国化工节能(减排)中心专家委员会委员;河南省天方药物化学工程实验室主任;郑州大学河南省化学生物与有机化学重点实验室 副主任;郑州大学化学学院教授委员会委员

课题组网站:www.zzuchem.com

教育与工作简历:

工作经历

2005-至今 郑州大学化学学院 教授

2007-至今 郑州大学河南省化学生物与有机化学重点实验室副主任

2010-至今 郑州大学化学学院硕士生导师、博士生导师

2006-2007 美国南加州大学药物化学系(University of Southern California)访问学者

1998-2005 郑州大学化学系 副教授 硕士生导师

学习经历

1983-1987 郑州大学化学系本科学习

1996-1997 英国瑞丁大学(Reading University)化学系留学

2001-2004 郑州大学化学系博士研究生 导师:赵玉芬院士

荣誉称号:2019年河南省高等学校教学名师;2019认定为河南省高层次人才;河南省本科教育线上教学优秀课程;2017年“河南省优秀科技型创新团队”主持人; 2012年获郑州大学“我最喜欢的老师”辛勤耕耘奖;2012年获郑州大学“创新启迪发展”女博导论坛优秀论文奖;2010年获郑州大学三育人先进个人

获奖情况:2006年获河南省科学技术进步奖一等奖;2005年获河南省教育厅学术技术带头人;2000年获河南省科学技术进步奖二等奖;1998年获河南省星火奖二等奖;2019年度郑州大学教学成果特等奖;2016年获郑州大学优秀研究生指导老师;2015年获河南省优秀硕士学位论文指导老师;

代表性科研成果:

主持科研项目

1、自由基加成串联反应构建聚集诱导发光效应新型芳香氮杂稠环,国家自然科学基金(No. 22071222)

2、基于Click反应三氮唑桥连双膦酸类化合物的设计、合成研究,国家自然科学基金(No. 21072178)

3、肿瘤靶位蛋白与磷酰化黄酮的弱相互作用研究,国家自然科学基金(No. 20472076)

4、磷酰化黄酮与蛋白弱相互作用和作用位点研究,河南省杰出青年基金项目(No. 054100001400)

5、新型抗骨质疏松双膦酸药物设计、合成及工艺优化,河南省科技创新人才计划(114200510023)

6、新型三氮唑双膦酸衍生物的合成与活性研究,郑州市科技领军人才(112PLJRC359)

7、博士学科点专项科研基金(20124101110003):基于Click反应1,2,3-三氮唑桥连新型双膦酸类化合物的设计、合成研究,高等学校

8、河南省优秀创新型科技团队主持:功能磷化合物设计合成及推广应用 (编号:16008)

主持两项国家级等教学项目:

  1. 有机化学双语教学,2010年国家双语教学示范课程。
  2. 2013 来华留学英语授课品牌课程(有机化学)。
  3. 2020 河南省高等学校精品在线开放课程。

二、代表性科研论文

  1. Yan Liu, Xiao-Lan Chen,* Xiao-Yun Li, Shan-Shan Zhu, Shi-Jun Li, Yan Song, Ling-Bo Qu, and Bing Yu*, 4CzIPN-tBu Catalyzed Proton-Coupled Electron Transfer for Photosynthesis of Phosphorylated N-Heteroaromatics. J. Am. Chem. Soc.2021, 143(2), 964-972.
  2. Kai Sun, Qi-Yan Lv* Xiao-Lan Chen,* Ling-Bo Qu, Bing Yu*, Recent Advances of Visible-Light-Mediated Organic Transformations in Water. Green Chem., 2021, 23(1), 232-248.
  3. Hu-Lin Zhu,# Fan-Lin Zeng,# Xiao-Lan Chen,* Kai Sun, Hao-Cong Li, Xiao-Ya Yuan, Ling-Bo Qu, Bing Yu*, Acyl Radicals from α-Keto Acids: Metal-Free Visible-Light-Promoted Acylation of Heterocycles, Org. Lett., 2021, DOI: 10.1021/acs.orglett.1c00655
  4. Fan-Lin Zeng, Xiao-Lan Chen,* Kai Sun,* Hu-Lin Zhu, Xiao-Ya Yuan, Yan Liu, Ling-Bo Qu, Yu-Fen Zhao, and Bing Yu*, Visible-Light-Induced Metal-Free Cascade Cyclization of N-arylpropiolamides to 3-Phosphorylated, Trifluoromethylated and Thiocyanated azaspiro[4.5]trienones. Org. Chem. Front., 2021, 8, 760-766
  5. Ya-Feng Si,# Kai Sun,# Xiao-Lan Chen,* Xiao-Yang Fu, Yan Liu, Fan-Lin Zeng, Tao Shi, Ling-Bo Qu, Bing Yu*, Arylaminomethyl radical-initiated cascade annulation reaction of quinoxalin-2(1H)-ones catalyzed by recyclable photocatalyst perovskite. Org. Lett., 2020, 22(17), 6960-6965
  6. Ya-Feng Si, Xiao-Lan Chen,* Xiao-Yang Fu, Kai Sun, Xiaojie Song, Ling-Bo Qu, and Bing Yu*, Divergent g-C3N4-catalyzed reactions of quinoxalin-2(1H)-ones with N-aryl glycines under visible light: Solvent-controlled hydroaminomethylation and annulation. ACS Sustainable Chem. Eng., 2020, 8(29), 10740-10746.
  7. Xiao-Yun Li#, Yan Liu#, Xiao-Lan Chen,* Xin-Yuan Lu, Xing-Xing Liang, Shan-Shan Zhu, Chuan-Wan Wei, Ling-Bo Qu, and Bing Yu*, 6π-Electrocyclization in Water: Microwave-Assisted Synthesis of Polyheterocyclic-Fused Quinoline-2-Thiones. Green Chem., 2020, 22(14), 4445-4449.
  8. Mehwish Hussain Muhammad, Xiao-Lan Chen,* Yan Liu, Tao Shi, Yuyu Peng, Lingbo Qu, and Bing Yu*, Recyclable [email protected]3N4-catalyzed hydroxylation of aryl boronic acids in water under visible-light: Synthesis of phenols under ambient condition and room temperature. ACS Sustainable Chem. Eng., 2020, 8, 7, 2682-2687.
  9. Xiao-Ceng Liu, Xiao-Lan Chen,* Yan Liu, Kai Sun, Yu-Yu Peng, Ling-Bo Qu, and Bing Yu*, Visible-Light-Induced Metal-Free Synthesis of 2‑Phosphorylated Thioflavones in Water. ChemSusChem, 2020, 13(2), 298-303.
  10. Fan Gao, Kai Sun,* Xiao-Lan Chen,* Tao Shi, Xiao-Yun Li, Ling-Bo Qu, Yu-Fen Zhao, Bing Yu*,Visible-light-induced Phosphorylation of Imidazo-fused Heterocycles under Metal-free Conditions. J. Org. Chem., 2020, 85(22), 14744-14752.
  11. Tao Shi,# Kai Sun,# Xiao-Lan Chen,* Zhao-Xin Zhang, Xian-Qiang Huang, Yu-Yu Peng, Ling-Bo Qu, and Bing Yu*, Recyclable Perovskite as Heterogeneous Photocatalyst for Aminomethylation of Imidazo-fused Heterocycles. Adv. Synth. Catal., 2020, 362(11), 2143-2149.
  12. Shuai-Qi He, Xiao-Lan Chen,* Fan-Lin Zeng, Pei-Pei Lu, Yu-Yu Peng, Ling-Bo Qu, and Bing Yu*, Visible-Light-Promoted Oxidative Decarboxylation of Arylacetic Acid in Air: Metal-Free Synthesis of Aldehydes and Ketones at Room Temperature. Chin. Chem. Lett., 2020, 31(7), 1863-1867.
  13. Yan Liu,# Shi-Jun Li,# Xiao-Lan Chen,* Lu-Lu Fan, Xiao-Yun Li, Shan-Shan Zhu, Ling-Bo Qu, and Bing Yu*, Mn(III)-Mediated Regioselective 6-endo-trig Radical Cyclization of o-Vinyl Arylisocyanides to Access 2-Functionalized Quinolines. Adv. Synth. Catal., 2020, 362(3), 688-694.
  14. Kai Sun, Xiao-Lan Chen,* Yin-Li Zhang, Kai Li*, Xian-Qiang Huang, Yu-Yu Peng, Ling-Bo Qu, and Bing Yu*, Metal-free Sulfonyl Radical-initiated Cascade Cyclization to Access Sulfonated Indolo[1,2-a]quinolines. Chem. Commun., 2019, 55, 12615-12618. (高被引论文)
  15. Yan Liu, Xiao-Lan Chen,* Kai Sun, Xiao-Yun Li, Fan-Lin Zeng, Xiao-Ceng Liu, Ling-Bo Qu, Yufen Zhao and Bing Yu*, Visible-Light Induced Radical Perfluoroalkylation/Cyclization Strategy to Access 2-Perfluoroalkylbenzothiazoles/benzoselenazoles by EDA Complex. Org. Lett., 2019, 21(11), 4019-4024.(热点论文、高被引论文)
  16. Fan-Lin Zeng, Xiao-Lan Chen,* Shuai-Qi He, Kai Sun, Yan Liu, Rui Fu, Ling-Bo Qu, Yu-Fen Zhao, and Bing Yu*, Copper-Catalyzed One-Pot Three-Component Thioamination of 1,4-Naphthoquinone. Org. Chem. Front., 2019, 6, 1476-1480.
  17. Junchao Wang,# Kai Sun,# Xiaolan Chen,* Tong Chen, Yan Liu, Lingbo Qu, Yufen Zhao, and Bing Yu*, An External-catalyst-free Trifluoromethylation/cyclization Strategy to Access Trifluoromethylated-Dihydroisoquinolinones/Indolines with Togni Reagent II. Org. Lett., 2019, 21, 1863-1867.(高被引论文)
  18. Kai Sun, Shi-Jun Li, Xiao-Lan Chen,* Yan Liu, Xian-Qiang Huang, Dong-Hui Wei*, Ling-Bo Qu, Yu-Fen Zhao, and Bing Yu*, Silver-Catalyzed Decarboxylative Radical Cascade Cyclization toward Benzimidazo[2,1-a]isoquinolin-6(5H)-ones. Chem. Commun., 2019, 55(19), 2861-2864. (高被引论文)
  19. Chunfeng Jing, Xiaolan Chen,* Kai Sun, Yongkang Yang, Tong Chen, Yan Liu, Lingbo Qu, Yufen Zhao, and Bing Yu*, Copper-Catalyzed C4-H Regioselective Phosphorylation/Trifluoromethylation of Free 1-Naphthylamines. Org. Lett., 2019, 21(2), 486-489. (高被引论文)
  20. Fan-Lin Zeng,# Kai Sun,# Xiao-Lan Chen,* Xiao-Ya Yuan, Shuai-Qi He, Yan Liu, Yu-Yu Peng, Ling-Bo Qu, Qi-Yan Lv, and Bing Yu*, Metal-Free Visible-Light Promoted Radical Cyclization to Access Perfluoroalkyl-Substituted Benzimidazo[2,1-a]isoquinolin-6(5H)-ones and Indolo[2,1-a]isoquinolin-6(5H)-ones. Adv. Synth. Catal., 2019, 361, 5176-5181
  21. Kai Sun#, Ya-Feng Si#, Xiao-Lan Chen,* Qi-Yan Lv, Nan Jiang, Shan-Shan Wang, Yu-Yu Peng, Ling-Bo Qu, and Bing Yu*, Silver-Catalyzed Radical Cascade Cyclization of Unactivated Alkenes towards Cyclopenta[c]quinolines. Adv. Synth. Catal., 2019, 361, 4483-4488
  22. Xiao-Ceng Liu#, Kai Sun#, Xiao-Lan Chen,* Wen-Fei Wang, Yan Liu, Qian-Li Li, Yu-Yu Peng, Ling-Bo Qu and Bing Yu*, Visible-Light-Promoted Transition-Metal-Free Approach toward Phosphoryl-Substituted Dihydroisoquinolones via Cascade Phosphorylation/Cyclization of N-Allylbenzamides. Adv. Synth. Catal., 2019, 361, 3712-3717
  23. Yin-Li Zhang,# Kai Sun,# Qi-Yan Lv, Xiao-Lan Chen,* Ling-Bo Qu, and Bing Yu*, Recent Applications of Radical Cascade Reaction in the Synthesis of Functionalized 1-Indenones. Chin. Chem. Lett., 2019, 30(7), 1361-1368. (热点论文、高被引论文)
  24. Hao Hu, Xiaolan Chen*, Kai Sun, Junchao Wang, Yan Liu, Hui Liu, Bing Yu*, Yuanqiang Sun, Lingbo Qu, and Yufen Zhao.Silver-Catalyzed Radical Cascade Cyclization toward 1,5-/1,3-Dicarbonyl Heterocycles: An Atom-/Step-Economical Strategy Leading to Chromenopyridines and Isoxazole-/Pyrazole-Containing Chroman-4-Ones. Org. Lett., 2018, 20, 6157-6160. (高被引论文)
  25. Hao Hu, Xiaolan Chen*, Kai Sun, Junchao Wang, Yan Liu, Hui Liu, Bing Yu*, Yuanqiang Sun, Lingbo Qu, and Yufen Zhao, Silver-catalyzed decarboxylative cascade radical cyclization of tert-carboxylic acids and o-(allyloxy)arylaldehydes towards chroman-4-one derivatives. Org. Chem. Front., 2018, 5(20), 2925-2929.
  26. Rui Li, Xiaolan Chen*, Shengkai Wei, Kai Sun, Lulu Fan, Yan Liu, Lingbo Qu, Yufen Zhao, and Bing Yu*. A visible-light-promoted metal-free strategy towards arylphosphonates: organic-dye-catalyzed phosphorylation of arylhydrazines with trialkylphosphites. Adv. Synth. Catal. 2018, 360, 4807-4813. (高被引论文)
  27. Kai Sun, Xiaolan Chen*, Shi-Jun Li, Dong-Hui Wei, Xiao-Ceng Liu, Yin-Li Zhang, Yan Liu, Lu-Lu Fan, Ling-Bo Qu, Bing Yu*, Kai Li, Yuan-Qiang Sun, and Yu-Fen Zhao. Copper-Catalyzed Radical Cascade Cyclization to Access 3-Sulfonated Indenones with AIE Phenomenon. J. Org. Chem., 2018, 83, 14419-14430
  28. Yan Liu, Xiao-Lan Chen*, Fan-Lin Zeng, Kai Sun, Chen Qu, Lu-Lu Fan, Zi-Long An, Rui Li, Chun-Feng Jing, Sheng-Kai Wei, Ling-Bo Qu, Bing Yu*, Yuan-Qiang Sun, and Yu-Fen Zhao, Phosphorus Radical-initiated Cascade Reaction to Access 2-Phosphoryl Substituted Quinoxalines, J. Org. Chem., 2018, 83, 11727-11735
  29. Yang, Yongkang; Qu, Chen; Chen, Xiaolan; Sun, Kai; Qu, Lingbo; Bi, Wenzhu; Hu, Hao; Li, Rui; Jing, Chunfeng; Wei, Donghui; Wei, Shengkai; Sun, Yuanqiang; Liu, Hui; Zhao, Yufen, A Multiheteroatom [3,3]-Sigmatropic Rearrangement: Disproportionative Entries into 2-(N-Heteroaryl)methyl Phosphates and α-Keto Phosphates. Org. Lett. 2017, 19 (21), 5864-5867. Highlighted by SynFacts (Synfacts 2019; 15(03): 0280)
  30. Bi, Wen-Zhu; Sun, Kai; Qu, Chen; Chen, Xiao-Lan; Qu, Ling-Bo; Zhu, Shao-Hua; Li, Xu; Wu, Hai-Tao; Duan, Li-Kun; Zhao, Yu-Fen, A direct metal-free C2-H functionalization of quinoline N-oxides: a highly selective amination and alkylation strategy towards 2-substituted quinolines. Org. Chem. Front., 2017, 4(8), 1595-1600.
  31. Gang Li, Chunqi Jia, Qingliang Chen, Kai Sun, Feng Zhao, Hankui Wu, Zhiyong Wang, Yunhe Lv, Xiaolan Chen, Copper(I)-Catalyzed Dehydrogenative Amidation of Arenes Using Air as the Oxidant. Adv. Synth. Catal. 2015, 357 (6), 1311-1315.
  32. Chen, Xin; Li, Xu; Chen, Xiao-Lan; Qu, Ling-Bo; Chen, Jian-Yu; Sun, Kai; Liu, Zhi-Dong; Bi, Wen-Zhu; Xia, Ying-Ya; Wu, Hai-Tao; Zhao, Yu-Fen, A one-pot strategy to synthesize beta-ketophosphonates: silver/copper catalyzed direct oxyphosphorylation of alkynes with H-phosphonates and oxygen in the air. Chem. Commun. 2015, 51 (18), 3846-3849
  33. Zhao, Wei-Ming; Chen, Xiao-Lan; Yuan, Jin-Wei; Qu, Ling-Bo; Duan, Li-Kun; Zhao, Yu-Fen, Silver catalyzed decarboxylative direct C2-alkylation of benzothiazoles with carboxylic acids.Chem. Commun. 2014, 50 (16), 2018-2020
  34. Xiaolan, Chen; Li, Xu; Qu, Zhibo; Ke, Diandian; Qu, Lingbo; Duan, Likun; Mai, Wenpeng; Yuan, Jinwei; Chen, Jianyu; Zhao, Yufen, H-Phosphonate-Mediated Amination of Quinoline N-Oxides with Tertiary Amines: A Mild and Metal-Free Synthesis of 2-Dialkylaminoquinolines. Adv. Synth. Catal. 2014, 356(9), 1979-1985
  35. Chen, Xiao-Lan; Li, Xu; Qu, Ling-Bo; Tang, Yu-Chun; Mai, Wen-Peng; Wei, Dong-Hui; Bi, Wen-Zhu; Duan, Li-Kun; Sun, Kai; Chen, Jian-Yu; Ke, Dian-Dian; Zhao, Yu-Fen, Peroxides as “Switches” of Dialkyl H-Phosphonate: Two Mild and Metal-Free Methods for Preparation of 2-Acylbenzothiazoles and Dialkyl Benzothiazol-2-ylphosphonates. J. Org. Chem. 2014, 79 (17), 8407-8416
  36. Chen, Xiao-Lan, Qu, Ling Bo, Zhang, Ting, Liu, Hong-Xia, Yu Fei, Yu, youzhu, Liao, Xincheng and Zhao, Yu-Fen. The nature of phosphorylated chrysin-protein interactions involved in noncovalent complex formation by electrospray ionization mass spectroscopy. Anal. Chem. 2004, 76 (1), 211-217.

出版专著:

  1. 医用基础化学(英文版)(主编), “十三五国家重点图书出版规划项目”,“一带一路背景下国际化临床医学丛书” ,郑州大学出版社,2021年
  2. 医用有机化学(英文版)(主编),“十三五国家重点图书出版规划项目”,“一带一路背景下国际化临床医学丛书”,郑州大学出版社,2021年
  3. 有机化学学习指导(副主编),郑州大学出版社(国家理科基地名牌课程建设参考书ISBN:978-7-81106-743-9),2008年
  4. 有机化学实验,中国医药科技出版社(高等医学院校教材ISBN:7-5067-1745-X/R.1518),2015年
  5. 有机化学学习指导,中国医药科技出版社(高等医学院校教学参考书ISBN:7-5067-1745-X/R.1521),2015年
  6. 生物有机质谱 郑州大学出版社(ISBN:7-81106-070-1/Q.2),2005年
  7. 磷与生活 郑州大学出版社(ISBN:978-7-81106-600-5),2005年