Research | 陈晓岚教授课题组

研究方向：

有机合成方法学/绿色有机合成/绿色催化/荧光分子探针

实验室长期从事有机合成方法学的研究工作，在有机合成新方法、绿色有机合成、绿色催化、可见光催化、有机磷化学等研究领域取得了突出的研究成果。

探索和开辟了系列构建C-P键，C-C键，C-S键，C-N键，C-O键的新型有机合成新方法

（1）开发了多种自由基引发的串联环化反应合成系列多环特别是杂环功能有机化合物的高效合成新方法。

（2）以H-亚磷酸酯作为优异的合成前体，在构建C-P键化合物以及实现氮杂环的选择性官能团化方面展现了具有重要的理论意义及应用价值的学术成绩，在磷化学合成方法领域做出了突出贡献。

（3）设计并成功合成了一系列以含1,2,3-三氮唑五元杂环等新型双膦酸类化合物及其荧光标记物，并深入开展了相关生物活性的检测，此研究对于新型双膦酸类化合物合成和进一步的开发应用奠定基础。

（4）在天然产物的分离、提取及结构鉴定、天然产物与药物分子的磷酰化结构改造、小分子与大分子相互作用等方面开展了出色的工作。相关研究成果发表在“ Anal. Chem. ” 和“Bioorg. Med. Chem. ”等国际知名杂志，其中“ Anal. Chem. ”上相关内容被 “ Chem. Rev. ”, “Nat. Prod. Rep.”, “J. Am. Soc. Mass Spectr.” 等引用，其中Chem. Rev. 用专门的段落对此项有意义的工作给予介绍。

开发新型荧光染料，研究生物活性硫化物、活性氧化物等生物活性物质的生理和化学性质，构建选择性识别活性硫化物和活性氧化物的荧光探针，实现生物活性物质在体内和体外的特异性荧光传感。

相关研究成果已陆续发表在“ Anal. Chem. ”, “ Chem. Commun. ”, “Org. Lett.”，“Adv. Synth. Catal. ”, “ J. Org. Chem. ”, “Bioconjugate Chem. ”, “Bioorg. Med. Chem. ”, “ Ultrason Sonochem. ” 等国内外知名SCI期刊90余篇。

Organic Synthetic Methodology/Green Catalysis/Functional Materials in Fluorescence Molecular Probe

1. Our Laboratory has long been engaged in developing highly efficient methodologies in organic synthesis. We have developed a series of novel methodologies of building C-P, C-C, C-S, C-N, C-O bonds.

(1) A series of highly efficient radical-initiated cascade cyclization methodologies toward various functionalized heterocycles have been successfully developed.

(2) A series of highly atom-/step- economical methodologies by using H-phosphonates as useful feedstocks for the construction of C-P bond and activation of N-oxides for the synthesis of various functionalized N-heterocycles have been developed. The new applications of H-phosphonates as synthetic building blocks from our laboratory has made an important contribution to the field phosphorus chemistry.

(3) Research works on design, synthesis, and biological evaluation of novel bisphosphonates have been successfully carried out;

(4) Our research works have also made progresses on natural product separation, extraction and structure identification, as well as phosphorylated modification of natural products and pharmaceutically important organic molecules. The non-covalent interactions of those phosphorylated molecules and the corresponding non-phosphorylated molecules with proteins were compared and deeply studied, demonstrating the important roles of the phosphorus moieties in biological responses and biological properties.

Related research results have been published in well-known international magazines, such as “Bioconjugate Chem.”, “Anal. Chem.”, “Bioorg. Med. Chem.”, “Ultrasonics Sonochemistry” etc. The meaningful works have been reviewed by “Chem. Rev.,” “Nat. Prod, The Rep.” and “J. Am. Soc. Mass Spectr.” etc.

2. Design and synthesize novel fluorescent dyes for the detecting of bioactive substances such as biological active sulfides, reactive oxides.

By far, we have been published over 90 SCI papers in well-known international magazines, such as “Anal. Chem.”, “Chem. Commun.”, “Org. Lett.” “Adv. Synth. Catal.”, “J. Org. Chem.”, “Bioconjugate Chem.”, “Bioorg. Med. Chem.”, “Ultrason Sonochem.” etc.